CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial
نویسندگان
چکیده
Mathilde Hunault, Jean-Luc Harousseau, Martine Delain, Malgorzata Truchan-Graczyk, Jean-Yves Cahn, Francis Witz, Thierry Lamy, Bernard Pignon, Jean-Pierre Jouet, Reda Garidi, Denis Caillot, Christian Berthou, Denis Guyotat, Alain Sadoun, Jean-Jacques Sotto, Bruno Lioure, Philippe Casassus, Philippe Solal-Celigny, Laure Stalnikiewicz, Bruno Audhuy, Odile Blanchet, Laurence Baranger, Marie-Christine Béné, and Norbert Ifrah, for the GOELAMS (Groupe Ouest-Est des Leucémies Aiguës et Maladies du Sang) Group
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid leukemia in remission: a report from the Children’s Cancer Group
Intensive, myelosuppressive therapy is necessary to maximize outcomes for patients with acute myeloid leukemia (AML). A comparison was made of 3 aggressive postremission approaches for children and adolescents with AML in a randomized trial, CCG2891.Atotal of 652 children and adolescents with AML who achieved remission on 2 induction regimens using identical drugs and doses (standard and intens...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Results of consecutive trials for children newly diagnosed with acute myeloid leukemia from the Australian and New Zealand Children’s Cancer Study Group
Despite improvements in the treatment of acute myeloid leukemia (AML), approximately 50% of children die of the disease. Clinical trials in adult patients with AML indicate that idarubicin may have superior efficacy when compared to daunorubicin in the remission-induction phases of chemotherapy. We conducted consecutive clinical trials in children with newly diagnosed AML in which daunorubicin ...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Larger numbers of CD4bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation
Relapse is the major cause of death after allogeneic bone marrow transplantation (BMT). This study tested the hypothesis that the numbers of donor mononuclear cells, lymphocytes, and CD341 cells influence relapse and event-free survival (EFS) after BMT. The study population consisted of 113 consecutive patients with hematologic malignancies who underwent non–T-cell–depleted BMT from HLAmatched ...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission
Allogeneic bone marrow transplantation (BMT) may be curative for more patients than chemotherapy for the child with relapsed acute lymphoblastic leukemia. This study reviewed the outcomes of 363 children with acute lymphoblastic leukemia in second remission who received unrelated donor BMT from 1988 to 2000 in order to define prognostic factors that affect leukemia-free survival (LFS). Median p...
متن کاملTotal body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines.
The influence of bone marrow transplantation (BMT) conditioning regimens on the incidence and severity of graft-versus-host disease (GVHD) has been suggested in clinical BMT. Using murine BMT models, we show here an increase in GVHD severity in several donor-recipient strain combinations after intensification of the conditioning regimen by increasing the total body irradiation (TBI) dose from 9...
متن کامل